|
|
17beta-estradiol + NADP+ <=> estrone + NADPH + H+
|
1.1.1.184
carbonyl reductase (NADPH)
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
1.1.1.64
testosterone 17beta-dehydrogenase (NADP+)
|
–
–
–
–
–
–
–
|
MK
|
|
BRENDA:
BR29326
KEGG:
R02353
MetaCyc:
ESTRADIOL-17-BETA-DEHYDROGENASE-RXN
SABIO-RK:
2301
|
|
|
|
17beta-estradiol + NAD+ <=> estrone + NADH + H+
|
1.1.1.210
3beta(or 20alpha)-hydroxysteroid dehydrogenase
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
1.1.1.300
NADP-retinol dehydrogenase
1.1.1.35
3-hydroxyacyl-CoA dehydrogenase
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.53
3alpha(or 20beta)-hydroxysteroid dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
|
–
–
–
–
–
–
–
–
|
K
|
|
BRENDA:
BR29326-a
KEGG:
R02352
MetaCyc:
ESTRADIOL-17-BETA-DEHYDROGENASE-RXN_WOP
SABIO-RK:
2300
|
|
|
|
O2 + reduced_acceptor + 17beta-estradiol <=> H2O + acceptor + 6beta-Hydroxyestradiol-17beta
|
1.14.99.11
estradiol 6beta-monooxygenase
|
–
|
K
|
|
BRENDA:
BR40395
KEGG:
R03086
MetaCyc:
ESTRADIOL-6-BETA-MONOOXYGENASE-RXN
|
|
|
|
UDP-glucuronate + 17beta-estradiol <=> estradiol_17-beta-D-glucuronide/in + UDP + H+
|
2.4.1
2.4.1.17
glucuronosyltransferase
|
–
–
|
|
|
BRENDA:
BS378069
MetaCyc:
RXN-19623
|
|
|
|
testosterone + 3 O2 + 3 reduced_flavodoxin <=> 17beta-estradiol + formate + 4 H2O + 3 flavin
|
1.14.14.14
aromatase
|
–
|
|
|
BRENDA:
BR50742
KEGG:
R10511
|
|
|
|
19-oxotestosterone + O2 + reduced_flavodoxin <=> 17beta-estradiol + formate + H2O + flavin
|
1.14.14.14
aromatase
|
–
|
K
|
|
BRENDA:
BR50745
KEGG:
R03087
|
|
|
|
17beta-estradiol + UDP-glucuronate <=> beta-estradiol-3-glucuronide + UDP
|
2.4.1.17
glucuronosyltransferase
|
–
|
K
|
|
BRENDA:
BS322185
KEGG:
R03091
SABIO-RK:
2931
|
|
|
|
3''-phosphoadenylylsulfate + 17beta-estradiol <=> adenosine_3'',5''-bisphosphate + estradiol_3-sulfate
|
2.8.2.1
aryl sulfotransferase
2.8.2.14
bile-salt sulfotransferase
2.8.2.15
steroid sulfotransferase
2.8.2.2
alcohol sulfotransferase
2.8.2.3
amine sulfotransferase
2.8.2.4
estrone sulfotransferase
|
–
–
–
–
–
–
|
K
|
|
BRENDA:
BS360260;
BS452476
KEGG:
R00535
SABIO-RK:
953
|
|
|
|
17beta-estradiol + H+ + O2 + NADPH <=> 2-hydroxyestradiol + NADP+ + H2O
|
1.14.14.1
unspecific monooxygenase
|
–
|
K
|
|
KEGG:
R03090
SABIO-RK:
2930
|
|
|
|
17beta-estradiol + H+ + O2 + NADH <=> 2-hydroxyestradiol + NAD+ + H2O
|
1.14.14.1
unspecific monooxygenase
|
–
|
K
|
|
KEGG:
R03088
|
|
|
|
17beta-estradiol + H+ + O2 + NADPH <=> estriol + NADP+ + H2O
|
1.14.14.1
unspecific monooxygenase
|
–
|
K
|
|
KEGG:
R03089
|
|
|
|
testosterone + reduced_[NADPH-hemoprotein_reductase] + O2 <=> 17beta-estradiol + oxidized_[NADPH-hemoprotein_reductase] + H2O + formate + H+
|
1.14.14.14
aromatase
|
–
|
|
|
MetaCyc:
RXN-14744
|
|
|
|
19-oxotestosterone + O2 + reduced_[NADPH-hemoprotein_reductase] <=> 17beta-estradiol + H2O + formate + oxidized_[NADPH-hemoprotein_reductase] + H+
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN66-349
|
|
|
|
testosterone + 3 O2 + 3 reduced_flavoproteins <=> 17beta-estradiol + formate + 4 H2O + 3 oxidized_flavoproteins
|
1.14.14.14
aromatase
|
–
|
|
|
BRENDA:
BS425049
|
|
|
|
estradiol_3-sulfate + H2O <=> 17beta-estradiol + sulfate
|
3.1.6.2
steryl-sulfatase
|
–
|
|
|
BRENDA:
BS407778
|
|
|
|
17beta-estradiol + UDP-glucuronate <=> estradiol_3-glucuronide + UDP
|
2.4.1.17
glucuronosyltransferase
|
–
|
|
|
BRENDA:
BS420663
|
|
|
|
17beta-estradiol + UDP-glucuronate <=> UDP + estradiol_O-glucuronide
|
2.4.1.17
glucuronosyltransferase
|
–
|
|
|
BRENDA:
BS322223
|
|
|
|
17beta-estradiol + UDP-glucuronate <=> UDP + beta-estradiol_3-O-glucuronide
|
2.4.1.17
glucuronosyltransferase
|
–
|
|
|
BRENDA:
BS455396
|
|
|
|
17beta-estradiol + UDP-glucuronate <=> UDP + estradiol_17-O-glucuronide
|
2.4.1.17
glucuronosyltransferase
|
–
|
|
|
BRENDA:
BS455653
|
|
|
|
17beta-estradiol + UDP-glucuronate <=> UDP + estradiol-3beta-D-glucuronoside
|
2.4.1.17
glucuronosyltransferase
|
–
|
|
|
BRENDA:
BS454813
|
|
|
|
17beta-estradiol + NADH <=> estrone + NAD+
|
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
|
–
–
|
|
|
BRENDA:
BS257221-a
|
|
|
|
17beta-estradiol + NADPH + O2 <=> 6beta-Hydroxyestradiol-17beta + NADP+ + H2O
|
1.14.99.11
estradiol 6beta-monooxygenase
|
–
|
|
|
BRENDA:
BS287969
|
|
|
|
17beta-estradiol + NADPH <=> estrone + NADP+
|
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
|
–
–
|
|
|
BRENDA:
BS257221
|
|
|
|
17beta-estradiol + NADPH + H+ + O2 <=> 1,3,5(10)-estratrien-3,7-alpha,17beta-triol + NADP+ + H2O
|
1.14.14.29
25/26-hydroxycholesterol 7alpha-hydroxylase
|
–
|
|
|
BRENDA:
BS375583
|
|
|
|
UDP-glucose + 17beta-estradiol <=> UDP + estradiol_3-beta-D-glucoside
|
2.4.1.173
sterol 3beta-glucosyltransferase
|
–
|
|
|
BRENDA:
BS435963
|
|
|
|
3''-phosphoadenylyl_sulfate + 17beta-estradiol <=> adenosine_3'',5''-bisphosphate + Estradiol_sulfate
|
2.8.2.1
aryl sulfotransferase
2.8.2.2
alcohol sulfotransferase
2.8.2.4
estrone sulfotransferase
|
–
–
–
|
|
|
BRENDA:
BS386069
|
|
|
|
3''-phosphoadenylylsulfate + 17beta-estradiol <=> adenosine_3'',5''-bisphosphate + 17alpha-Estradiol_3-sulfate
|
2.8.2.4
estrone sulfotransferase
|
–
|
|
|
BRENDA:
BS360477
|
|
|
|
4-nitrophenyl_sulfate + 17beta-estradiol <=> Estradiol_sulfate + 4-nitrophenol
|
2.8.2.22
aryl-sulfate sulfotransferase
|
–
|
|
|
BRENDA:
BS360412
|
|
|
|
ATP + H2O + 17beta-estradiol <=> ADP + phosphate + 17beta-estradiol
|
7.6.2.2
ABC-type xenobiotic transporter
|
–
|
|
|
BRENDA:
BS404387
|
|
|
|
estradiol-17-beta-oleate + H2O <=> 17beta-estradiol + oleic_acid
|
3.1.1.79
hormone-sensitive lipase
|
–
|
|
|
BRENDA:
BS373164
|
|
|
|
estradiol-17-beta-palmitate + H2O <=> 17beta-estradiol + palmitate
|
3.1.1.79
hormone-sensitive lipase
|
–
|
|
|
BRENDA:
BS373165
|
|
|
|
17beta-estradiol-3''-beta-D-glucoside + H2O <=> beta-D-glucose + 17beta-estradiol
|
3.2.1.21
beta-glucosidase
|
–
|
|
|
BRENDA:
BS214494
|
|
|
|
H+ + O2 + NADPH + testosterone <=> H2O + NADP+ + formate + 17beta-estradiol
|
1.14.14.1
unspecific monooxygenase
|
–
|
|
|
SABIO-RK:
9545
|
|
|
|
17beta-estradiol + H+ + NADPH + O2 <=> 4-hydroxyestradiol + NADP+ + H2O
|
1.14.14.1
unspecific monooxygenase
|
–
|
|
|
SABIO-RK:
13321
|
|
|
|
3''-Phosphoadenylyl_sulfate + 17beta-estradiol <=> Estradiol_17-sulfate + Adenosine_3'',5''-bisphosphate
|
not assigned
|
–
|
|
|
SABIO-RK:
15236
|
|